Aguilar-Guadarrama A Berenice, Rios María Yolanda
Centro de Investigaciones Químicas de la Universidad Autónoma del Estado de Morelos, Chamilpa, Cuernavaca, Mor., México.
Planta Med. 2004 Jan;70(1):85-6. doi: 10.1055/s-2004-815465.
Through a bioactivity-guided fractionation from the acetone extract of the leaves from Esenbeckia yaaxhokob geranyl N-dimethylallylanthranilate ( 1), the first natural N- and O-prenylated anthranilate, was isolated in addition of the known natural products caryophyllene beta-oxide, caryolane-5beta,9beta-diol, spathulenol ( 2), friedeline, friedelanol, decaprenol, flindersiamine ( 3) and beta-sitosterol. The antimicrobial activities of the extract, fractions and pure compounds were evaluated against two Gram (+) and four Gram (-) bacteria. Compounds 1 and 2 exhibited moderated antimicrobial activity against Staphyloccocus aureus, while 3 was active against S. aureus and Streptococcus faecalis.
通过对牙买加伊塞恩贝克叶丙酮提取物进行生物活性导向分离，除了分离出已知天然产物β-石竹烯氧化物、蒈烷-5β,9β-二醇、匙叶桉油烯醇（2）、木栓酮、木栓醇、癸异戊二烯醇、弗林德胺（3）和β-谷甾醇外，还分离出了首个天然的N-和O-异戊烯基化邻氨基苯甲酸酯香叶基N-二甲基烯丙基邻氨基苯甲酸酯（1）。对提取物、馏分和纯化合物针对两种革兰氏阳性菌和四种革兰氏阴性菌的抗菌活性进行了评估。化合物1和2对金黄色葡萄球菌表现出中等抗菌活性，而化合物3对金黄色葡萄球菌和粪肠球菌有活性。
