Jehle Andreas W, Khanna Nina, Sigle Jörg-Peter, Glatz-Krieger Katharina, Battegay Manuel, Steiger Jürg, Dickenmann Michael, Hirsch Hans H
Division of Transplantation Immunology and Nephrology, University Hospitals Basel, Basel, Switzerland.
Clin Infect Dis. 2004 Feb 15;38(4):e32-5. doi: 10.1086/381441. Epub 2004 Jan 30.
Immune reconstitution syndrome following HAART in human immunodeficiency virus (HIV)-infected patients is characterized by inflammatory worsening of organ functions despite improvement in HIV surrogate markers of HIV infection. We describe a patient with miliary tuberculosis and urinary shedding of acid fast bacilli who developed acute renal failure 8 weeks after initiation of antituberculosis therapy and 6 weeks after initiation of HAART. The diagnostic workup and further course of disease implicated immune reconstitution syndrome as the cause of acute renal failure.
人类免疫缺陷病毒（HIV）感染患者接受高效抗逆转录病毒治疗（HAART）后出现的免疫重建综合征，其特征是尽管HIV感染的替代标志物有所改善，但器官功能仍出现炎症性恶化。我们描述了一名患有粟粒性肺结核且尿中排酸杆菌的患者，该患者在开始抗结核治疗8周后以及开始HAART 6周后出现急性肾衰竭。诊断检查和疾病的进一步发展表明免疫重建综合征是急性肾衰竭的病因。
