Pierro Agostino, Eaton Simon
Department of Paediatric Surgery, The Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, University College London, London, UK.
Semin Pediatr Surg. 2004 Feb;13(1):11-7. doi: 10.1053/j.sempedsurg.2003.09.003.
Intestinal ischemia-reperfusion is a common pathway for many diseases in infants, children, and adults, and this may lead to multiple organ dysfunction syndrome and death. While several studies have investigated reperfusion injury in cardiac, cerebral, and hepatic disease, limited work has been published on intestinal ischemia-reperfusion and its multiorgan effects. The authors have developed models of intestinal ischemia-reperfusion in rats and have demonstrated that intestinal reperfusion causes liver energy failure at normothermia. This is followed by 100% mortality within 4 hours of reperfusion. Moderate hypothermia (32 degrees C to 33 degrees C) induced throughout ischemia and reperfusion prevents liver energy failure, intestinal damage, and neutrophil infiltration in the lungs. Moderate hypothermia in this model of intestinal ischemia and reperfusion prevents mortality. Further studies are needed to establish whether therapeutic hypothermia is a useful intervention in the treatment of infants and children with intestinal injuries caused by ischemia and reperfusion.
肠缺血再灌注是婴儿、儿童和成人多种疾病的常见发病途径，这可能导致多器官功能障碍综合征和死亡。虽然有多项研究调查了心脏、大脑和肝脏疾病中的再灌注损伤，但关于肠缺血再灌注及其多器官影响的研究报道较少。作者建立了大鼠肠缺血再灌注模型，并证明肠再灌注在常温下会导致肝脏能量衰竭。随后，再灌注后4小时内死亡率达100%。在整个缺血和再灌注过程中诱导的中度低温（32摄氏度至33摄氏度）可预防肝脏能量衰竭、肠道损伤和肺部中性粒细胞浸润。在该肠缺血再灌注模型中，中度低温可预防死亡。需要进一步研究以确定治疗性低温是否是治疗因缺血再灌注导致肠损伤的婴幼儿的有效干预措施。
