先天性异常中柔脑膜神经胶质神经元异位的临床病理研究

Clinicopathologic studies on leptomeningeal glioneuronal heterotopia in congenital anomalies.

作者信息

Hirano S, Houdou S, Hasegawa M, Kamei A, Takashima S

机构信息

Division of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Tokyo, Japan.

出版信息

Pediatr Neurol. 1992 Nov-Dec;8(6):441-4. doi: 10.1016/0887-8994(92)90006-k.

DOI:10.1016/0887-8994(92)90006-k

PMID:1476573

Abstract

Leptomeningeal glioneuronal heterotopia was observed in 40 of 129 autopsied infants (31%). It was present in 49% of patients who had congenital anomalies in general and in 65% of patients who had central nervous system malformations. Most of the leptomeningeal glioneuronal heterotopias appeared in the base of the brain (62.5%), midbrain (40%), frontal lobe (37%), and pons (35%). Leptomeningeal glioneuronal heterotopia is closely related to migration disorders on the basis of frequent association with polymicrogyria or neuronal heterotopias.

摘要

在129例接受尸检的婴儿中，40例（31%）观察到软脑膜神经胶质神经元异位。在一般有先天性异常的患者中，其发生率为49%；在有中枢神经系统畸形的患者中，发生率为65%。大多数软脑膜神经胶质神经元异位出现在脑底部（62.5%）、中脑（40%）、额叶（37%）和脑桥（35%）。基于软脑膜神经胶质神经元异位常与多小脑回或神经元异位相关，它与迁移障碍密切相关。