Heidelberger Ruth, Matthews Gary
Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, TX 77030 USA, USA.
Neuron. 2004 Feb 5;41(3):311-3. doi: 10.1016/s0896-6273(04)00039-x.
Synapses have a limited pool of vesicles that are docked and primed for rapid release. In neuroendocrine cells, splice variants of the SNARE protein SNAP-25 and phosphorylation of SNAP-25 independently influence the size of the releasable vesicle pool, possibly by altering the rate of vesicle depriming. Pre- and posttranslational modifications of SNAP-25 may therefore affect synaptic strength.
突触具有有限的囊泡池，这些囊泡停靠并准备好进行快速释放。在神经内分泌细胞中，SNARE蛋白SNAP - 25的剪接变体和SNAP - 25的磷酸化独立影响可释放囊泡池的大小，可能是通过改变囊泡去引发的速率。因此，SNAP - 25的翻译前和翻译后修饰可能会影响突触强度。
