Castro-Alamancos Manuel A
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA.
Neuron. 2004 Feb 5;41(3):455-64. doi: 10.1016/s0896-6273(03)00853-5.
One prominent feature of sensory responses in neocortex is that they rapidly adapt to increases in frequency, a process called "sensory adaptation." Here we show that sensory adaptation mainly occurs during quiescent states such as anesthesia, slow-wave sleep, and awake immobility. In contrast, during behavior-ally activated states, sensory responses are already adapted. For instance, during learning of a behavioral task, when an animal is very alert and expectant, sensory adaptation is mostly absent. After learning occurs, and the task becomes routine, the level of alertness lessens and sensory adaptation becomes robust. The primary sensory thalamocortical pathway of alert and expectant animals is in the adapted state, which may be required for adequate sensory information processing.
新皮层感觉反应的一个显著特征是它们会迅速适应频率增加，这一过程称为“感觉适应”。我们在此表明，感觉适应主要发生在诸如麻醉、慢波睡眠和清醒不动等静止状态期间。相比之下，在行为激活状态下，感觉反应已经适应。例如，在行为任务学习期间，当动物非常警觉且充满期待时，感觉适应大多不存在。学习发生后，任务变得常规，警觉性降低，感觉适应变得强烈。警觉且充满期待的动物的主要感觉丘脑皮质通路处于适应状态，这可能是充分处理感觉信息所必需的。
