Creasman William T, Kohler Matthew F
Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC 29425, USA.
Gynecol Oncol. 2004 Feb;92(2):525-9. doi: 10.1016/j.ygyno.2003.11.020.
To determine whether lymph vascular space involvement (LVSI) in women with early cervical carcinoma is an independent prognostic factor.
The literature was reviewed using Medline and known literature to determine if LVSI is an independent risk factor as determined by multivariant analysis with survival being the end point in patients undergoing radical hysterectomy and pelvic lymphadenopathy.
A total of 25 articles were identified that satisfied the evaluation criteria. Only three (12%) identified LVSI as an independent risk factor while 88% and 61% of those evaluated, noted lymph node metastasis and tumor size/depth of invasion to be significant risk factors for survival.
Using LVSI as the sole determining factor for consideration of post radical hysterectomy radiotherapy appears questionable.
确定早期宫颈癌女性患者的淋巴管间隙受累（LVSI）是否为独立的预后因素。
使用医学文献数据库（Medline）及已知文献进行综述，以确定LVSI是否为多变量分析确定的独立危险因素，该分析以接受根治性子宫切除术和盆腔淋巴结清扫术患者的生存情况作为终点。
共识别出25篇符合评估标准的文章。仅有3篇（12%）将LVSI确定为独立危险因素，而在接受评估的患者中，分别有88%和61%指出淋巴结转移及肿瘤大小/浸润深度是生存的显著危险因素。
将LVSI作为根治性子宫切除术后放疗考虑的唯一决定因素似乎存在疑问。
