Blackman Alexandra, Creasman William
Department of Obstetrics & Gynecology, Medical University of South Carolina, Charleston, SC 29425, USA.
Cancers (Basel). 2023 Oct 19;15(20):5051. doi: 10.3390/cancers15205051.
Cervical cancer remains a significant public health concern within the United States and across the world. Cervical cancer is most frequently diagnosed in women between the ages of 35 and 44 and therefore affects a younger patient population than many other cancers. The management of early-stage disease has frequently utilized radical hysterectomy with the associated increased surgical morbidity, without clear evidence of any benefits. In stage IA disease, there are retrospective pathologic data supporting the safety of conservative surgery and lymphadenectomy over radical hysterectomy. There are also emerging prospective studies supporting conservative management. This editorial presents the evidence for conservative management of stage IA cervical cancer by reviewing the existing retrospective studies as well as the ongoing prospective studies.
宫颈癌在美国乃至全球仍是一个重大的公共卫生问题。宫颈癌最常被诊断于35至44岁的女性,因此与许多其他癌症相比,它影响的是更年轻的患者群体。早期疾病的治疗常常采用根治性子宫切除术,这会增加手术发病率,却没有明确的证据表明有任何益处。在IA期疾病中,有回顾性病理数据支持保守手术和淋巴结清扫术比根治性子宫切除术更安全。也有新出现的前瞻性研究支持保守治疗。这篇社论通过回顾现有的回顾性研究以及正在进行的前瞻性研究,展示了IA期宫颈癌保守治疗的证据。