Ghiu Ioana A, Ferrell Robert E, Kulaputana Onanong, Phares Dana A, Hagberg James M
Department of Kinesiology, University of Maryland, College Park, MD 20742-2611, USA.
J Appl Physiol (1985). 2004 Mar;96(3):985-90. doi: 10.1152/japplphysiol.00877.2003.
We assessed the effects of coagulation factor VII (FVII) gene polymorphisms, lipid-related polymorphisms, and exercise training-induced plasma lipoprotein lipid changes on FVII level changes with exercise training in middle- to older-aged men and women. Forty-six healthy sedentary men and women were stabilized on a low-fat diet and then underwent baseline testing, 6 mo of endurance exercise training, and final testing. Plasma FVII-Ag levels decreased with exercise training (106.7 +/- 1.4 vs. 104.2 +/- 1.6%, P = 0.005). There were no significant differences in FVII-Ag changes with exercise training between -323 (0/10 bp)/-401 (G/T) haplotype or -402 (G/A) genotype groups. FVII-Ag changes with training were not correlated with changes in plasma lipoprotein lipids. In linear regression analyses, FVII-Ag changes with training remained significant after adjusting for training-induced plasma lipoprotein lipid changes (P = 0.01). FVII changes with training were associated with apolipoprotein E genotype (P = 0.012); this relationship was still evident after adjusting for training-induced plasma lipoprotein lipid changes (P = 0.047). FVII changes with training also were significantly associated with human ATPase binding cassette-1 genotype (P = 0.018); this relationship persisted after accounting for the effect of the training-induced plasma lipoprotein lipid changes (P = 0.045). We conclude that plasma FVII-Ag changes with exercise training are more closely related to selected lipid-related genotypes than FVII gene promoter variants.
我们评估了凝血因子VII（FVII）基因多态性、脂质相关多态性以及运动训练诱导的血浆脂蛋白脂质变化对中老年男性和女性运动训练后FVII水平变化的影响。46名久坐不动的健康男性和女性先采用低脂饮食使其状态稳定，然后进行基线测试、6个月的耐力运动训练以及最终测试。运动训练后血浆FVII - Ag水平下降（106.7±1.4 vs. 104.2±1.6%，P = 0.005）。-323（0/10 bp）/-401（G/T）单倍型或-402（G/A）基因型组之间，运动训练后FVII - Ag变化无显著差异。FVII - Ag的训练变化与血浆脂蛋白脂质变化无相关性。在线性回归分析中，调整训练诱导的血浆脂蛋白脂质变化后，FVII - Ag的训练变化仍具有显著性（P = 0.01）。FVII的训练变化与载脂蛋白E基因型相关（P = 0.012）；调整训练诱导的血浆脂蛋白脂质变化后，这种关系仍然明显（P = 0.047）。FVII的训练变化还与人类ATP酶结合盒-1基因型显著相关（P = 0.018）；考虑训练诱导的血浆脂蛋白脂质变化的影响后，这种关系依然存在（P = 0.045）。我们得出结论，运动训练引起的血浆FVII - Ag变化与特定脂质相关基因型的关系比与FVII基因启动子变异的关系更为密切。
