Sugawara Jun, Hayashi Koichiro, Kurachi Sumiko, Tanaka Taku, Yokoi Takashi, Kurachi Kotoku
Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 6, Tsukuba, Ibaraki 305-8566, Japan.
J Thromb Thrombolysis. 2008 Dec;26(3):203-10. doi: 10.1007/s11239-007-0092-y. Epub 2007 Sep 10.
Age-related changes in blood coagulation and fibrinolytic factors are associated with an increase in risk of thrombotic events. The purpose of this study was to assess the effects of age, regular aerobic exercise and detraining on blood coagulation and fibrinolytic factors in men.
Initially, 41 sedentary and 42 physically active men (20-64 years) were analyzed for plasma levels of coagulation and fibrinolytic factors. Twelve sedentary men were then subjected to 16-week aerobic exercise training and subsequent 2-week detraining. Their blood samples taken at rest were assayed for activity levels of prothrombin, coagulation factor (F) V, VII, VIII, IX, X, XI and XIII, antithrombin III, protein C and plasminogen, and for antigen levels of fibrinogen, prothrombin fragment 1 + 2 (F1 + 2), FIX, protein C, tissue-type plasminogen activator (tPA), plasminogen activator inhibitor 1 (PAI-1) and tPA/PAI-1 complex.
Plasma levels of most coagulation factors, particularly for fibrinogen and FIX antigens as well as FXIII activity significantly increased with aging in sedentary men, while that tendency disappeared in physically active men. By the exercise training, plasma antigen and/or activity levels of most blood coagulation factors except for prothrombin and FIX decreased. These training-effects, however, disappeared after detraining, and in some cases even rebounded to higher levels than those of pre-training. Plasma antigen levels of tPA, PAI-1 and tPA/PAI-1 complex decreased with the training and remained low even after detraining.
Regular aerobic exercises give complex effects on expression of hemostatic factors, overall favoring the hemostatic balance to less thrombotic, partly cancelling out the age effects.
血液凝固和纤维蛋白溶解因子的年龄相关变化与血栓形成事件风险增加有关。本研究的目的是评估年龄、规律有氧运动和停训对男性血液凝固和纤维蛋白溶解因子的影响。
最初，对41名久坐不动和42名身体活跃的男性（20 - 64岁）进行血浆凝固和纤维蛋白溶解因子水平分析。然后，12名久坐不动的男性接受为期16周的有氧运动训练，随后进行为期2周的停训。对他们静息时采集的血样检测凝血酶原、凝血因子（F）V、VII、VIII、IX、X、XI和XIII、抗凝血酶III、蛋白C和纤溶酶原的活性水平，以及纤维蛋白原、凝血酶原片段1 + 2（F1 + 2）、FIX、蛋白C、组织型纤溶酶原激活剂（tPA）、纤溶酶原激活剂抑制剂1（PAI - 1）和tPA/PAI - 1复合物的抗原水平。
久坐不动的男性中，大多数凝血因子的血浆水平，特别是纤维蛋白原和FIX抗原以及FXIII活性随年龄显著增加，而在身体活跃的男性中这种趋势消失。通过运动训练，除凝血酶原和FIX外，大多数凝血因子的血浆抗原和/或活性水平降低。然而，这些训练效果在停训后消失，在某些情况下甚至反弹至高于训练前的水平。tPA、PAI - 1和tPA/PAI - 1复合物的血浆抗原水平随训练降低，即使在停训后仍保持较低水平。
规律的有氧运动对止血因子的表达产生复杂影响，总体上有利于止血平衡向血栓形成减少的方向发展，部分抵消了年龄的影响。
