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Comparison of LCx with other current viral load assays for detecting and quantifying human immunodeficiency virus type 1 RNA in patients infected with the circulating recombinant form A/G (CRF02).在感染循环重组形式A/G（CRF02）的患者中，将LCx与其他当前病毒载量检测方法用于检测和定量1型人类免疫缺陷病毒RNA的比较。
J Clin Microbiol. 2004 Feb;42(2):811-5. doi: 10.1128/JCM.42.2.811-815.2004.
2
Multicenter study of the LCx HIV RNA quantitative assay--a new competitive reverse transcriptase-PCR which targets pol genomic region of HIV-1 for the measurement of type B, non-type B and group O HIV-1 RNA.LCx HIV RNA定量检测的多中心研究——一种新型竞争性逆转录聚合酶链反应，靶向HIV-1的pol基因组区域，用于检测B型、非B型和O组HIV-1 RNA 。
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Comparative performance of three viral load assays on human immunodeficiency virus type 1 (HIV-1) isolates representing group M (subtypes A to G) and group O: LCx HIV RNA quantitative, AMPLICOR HIV-1 MONITOR version 1.5, and Quantiplex HIV-1 RNA version 3.0.三种病毒载量检测方法对代表M组（A至G亚型）和O组的1型人类免疫缺陷病毒（HIV-1）分离株的比较性能：LCx HIV RNA定量检测、AMPLICOR HIV-1 MONITOR版本1.5以及Quantiplex HIV-1 RNA版本3.0。
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2
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3
Comparative evaluation of the performance of the Abbott real-time human immunodeficiency virus type 1 (HIV-1) assay for measurement of HIV-1 plasma viral load following automated specimen preparation.在自动样本制备后，对雅培实时1型人类免疫缺陷病毒（HIV-1）检测法检测HIV-1血浆病毒载量的性能进行比较评估。
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本文引用的文献

1
Underevaluation of HIV-1 plasma viral load by a commercially available assay in a cluster of patients infected with HIV-1 A/G circulating recombinant form (CRF02).在一群感染HIV-1 A/G循环重组型（CRF02）的患者中，一种商用检测方法对HIV-1血浆病毒载量的评估不足。
J Acquir Immune Defic Syndr. 2002 Dec 15;31(5):488-94. doi: 10.1097/00126334-200212150-00006.
2
Multicenter study of the LCx HIV RNA quantitative assay--a new competitive reverse transcriptase-PCR which targets pol genomic region of HIV-1 for the measurement of type B, non-type B and group O HIV-1 RNA.LCx HIV RNA定量检测的多中心研究——一种新型竞争性逆转录聚合酶链反应，靶向HIV-1的pol基因组区域，用于检测B型、非B型和O组HIV-1 RNA 。
Clin Chem Lab Med. 2002 Jul;40(7):698-704. doi: 10.1515/CCLM.2002.120.
3
Monophyletic HIV type 1 CRF02-AG in a nosocomial outbreak in Benghazi, Libya.利比亚班加西医院爆发中出现的单系HIV-1 CRF02-AG毒株。
AIDS Res Hum Retroviruses. 2002 Jul 1;18(10):727-32. doi: 10.1089/088922202760072366.
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Comparative analysis of HIV-1 viral load assays on subtype quantification: Bayer Versant HIV-1 RNA 3.0 versus Roche Amplicor HIV-1 Monitor version 1.5.HIV-1病毒载量检测在亚型定量方面的比较分析：拜耳Versant HIV-1 RNA 3.0与罗氏Amplicor HIV-1 Monitor版本1.5
J Acquir Immune Defic Syndr. 2002 Apr 1;29(4):330-9. doi: 10.1097/00126334-200204010-00002.
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Estimated global distribution and regional spread of HIV-1 genetic subtypes in the year 2000.2000年全球人类免疫缺陷病毒1型基因亚型的估计分布及区域传播情况。
J Acquir Immune Defic Syndr. 2002 Feb 1;29(2):184-90. doi: 10.1097/00042560-200202010-00013.
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Increasing prevalence of non-clade B HIV-1 strains in heterosexual men and women, as monitored by analysis of reverse transcriptase and protease sequences.通过对逆转录酶和蛋白酶序列的分析监测发现，异性恋男性和女性中非B亚型HIV-1毒株的流行率不断上升。
J Acquir Immune Defic Syndr. 2001 Aug 15;27(5):499-505. doi: 10.1097/00126334-200108150-00012.
7
Erroneously low or undetectable plasma human immunodeficiency virus type 1 (HIV-1) ribonucleic acid load, determined by polymerase chain reaction, in West African and American patients with non-B subtype HIV-1 infection.在西非和美国感染非B亚型人类免疫缺陷病毒1型（HIV-1）的患者中，通过聚合酶链反应测定的血浆HIV-1核糖核酸载量错误地偏低或检测不到。
Clin Infect Dis. 2001 Apr 15;32(8):1227-30. doi: 10.1086/319752. Epub 2001 Apr 2.
8
Comparative performance of three viral load assays on human immunodeficiency virus type 1 (HIV-1) isolates representing group M (subtypes A to G) and group O: LCx HIV RNA quantitative, AMPLICOR HIV-1 MONITOR version 1.5, and Quantiplex HIV-1 RNA version 3.0.三种病毒载量检测方法对代表M组（A至G亚型）和O组的1型人类免疫缺陷病毒（HIV-1）分离株的比较性能：LCx HIV RNA定量检测、AMPLICOR HIV-1 MONITOR版本1.5以及Quantiplex HIV-1 RNA版本3.0。
J Clin Microbiol. 2001 Mar;39(3):862-70. doi: 10.1128/JCM.39.3.862-870.2001.
9
An outbreak of the circulating recombinant form AECM240 HIV-1 in the Finnish injection drug user population.芬兰注射吸毒人群中出现循环重组形式AECM240 HIV-1的疫情。
AIDS. 2000 Nov 10;14(16):2613-5. doi: 10.1097/00002030-200011100-00028.
10
Use of calibrated viral load standards for group M subtypes of human immunodeficiency virus type 1 to assess the performance of viral RNA quantitation tests.使用针对1型人类免疫缺陷病毒M组亚型的校准病毒载量标准品来评估病毒RNA定量检测的性能。
J Clin Microbiol. 2000 Mar;38(3):1247-9. doi: 10.1128/JCM.38.3.1247-1249.2000.

在感染循环重组形式A/G（CRF02）的患者中，将LCx与其他当前病毒载量检测方法用于检测和定量1型人类免疫缺陷病毒RNA的比较。

Comparison of LCx with other current viral load assays for detecting and quantifying human immunodeficiency virus type 1 RNA in patients infected with the circulating recombinant form A/G (CRF02).

作者信息

Amendola Alessandra, Bordi Licia, Angeletti Claudio, Girardi Enrico, Ippolito Giuseppe, Capobianchi Maria R

机构信息

National Institute for Infectious Diseases "Lazzaro Spallanzani," Rome, Italy.

出版信息

J Clin Microbiol. 2004 Feb;42(2):811-5. doi: 10.1128/JCM.42.2.811-815.2004.

DOI:10.1128/JCM.42.2.811-815.2004
PMID:14766858
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC344458/
Abstract

LCx was compared to other assays in measuring human immunodeficiency virus type 1 (HIV-1) CRF02 viremia. LCx showed significant but low correlation with the other methods. Values of <2.60 log(10) cp/ml were observed in 29.6% of specimens with LCx and in only 14.8% with bDNA and PCR, suggesting suboptimal performance of LCx with CRF02.

摘要

在测量1型人类免疫缺陷病毒（HIV-1）CRF02病毒血症方面，将LCx与其他检测方法进行了比较。LCx与其他方法显示出显著但较低的相关性。使用LCx检测时，29.6%的标本检测值<2.60 log(10) cp/ml，而使用分支DNA（bDNA）和聚合酶链反应（PCR）检测时，这一比例仅为14.8%，提示LCx对CRF02的检测性能欠佳。