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在感染携带L74V或与胸苷相关突变的病毒的病例中，停用抗逆转录病毒治疗后出现的不同病毒反弹情况。

Different viral rebound following discontinuation of antiretroviral therapy in cases of infection with viruses carrying L74V or thymidine-associated mutations.

作者信息

de Mendoza Carmen, Paxinos Ellen, Barreiro Pablo, Camino Nuria, Núñez Marina, Soriano Vincent

机构信息

Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain.

出版信息

J Clin Microbiol. 2004 Feb;42(2):862-6. doi: 10.1128/JCM.42.2.862-866.2004.

DOI:10.1128/JCM.42.2.862-866.2004
PMID:14766874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC344444/
Abstract

A total of 76 patients discontinued treatment with didanosine plus hydroxyurea after 1 year of maintenance therapy. The greatest human immunodeficiency virus (HIV)-RNA rebounds were seen in 10 patients harboring an L74V mutation, and the presence of viruses with this mutation rapidly waned. In contrast, viral rebounds were significantly less pronounced (P < 0.01) in 12 subjects harboring thymidine-associated mutations; these mutations persisted in all instances. Thus, selection of an L74V mutation during didanosine therapy may compromise HIV replication in vivo.

摘要

共有76例患者在接受1年维持治疗后停止使用去羟肌苷加羟基脲治疗。在10例携带L74V突变的患者中观察到最大的人类免疫缺陷病毒（HIV）-RNA反弹，且携带该突变的病毒迅速减少。相比之下，12例携带胸苷相关突变的受试者的病毒反弹明显不那么明显（P<0.01）；这些突变在所有情况下均持续存在。因此，在去羟肌苷治疗期间选择L74V突变可能会损害体内HIV的复制。

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本文引用的文献

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HIV Clin Trials. 2003 Nov-Dec;4(6):361-71. doi: 10.1310/4GMU-AG3T-Q3CC-GE5D.
2
Drug resistance mutations in HIV-1.HIV-1中的耐药性突变
Top HIV Med. 2003 May-Jun;11(3):92-6.
3
Antiretroviral drug resistance testing in adults infected with human immunodeficiency virus type 1: 2003 recommendations of an International AIDS Society-USA Panel.1型人类免疫缺陷病毒感染成人的抗逆转录病毒药物耐药性检测：美国国际艾滋病学会专家组2003年建议
Clin Infect Dis. 2003 Jul 1;37(1):113-28. doi: 10.1086/375597. Epub 2003 Jun 23.
4
Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions.
AIDS. 2002 Nov 22;16(17):2342-4. doi: 10.1097/00002030-200211220-00018.
5
Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection.在慢性HIV感染中，通过结构化治疗中断刺激HIV特异性细胞免疫未能增强病毒控制。
Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13747-52. doi: 10.1073/pnas.202372199. Epub 2002 Oct 7.
6
Interruption of antiretroviral therapy to augment immune control of chronic HIV-1 infection: risk without reward.中断抗逆转录病毒疗法以增强对慢性HIV-1感染的免疫控制：有风险而无益处。
Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13377-8. doi: 10.1073/pnas.212518999. Epub 2002 Oct 7.
7
Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adults.人类免疫缺陷病毒感染成人接受蛋白酶抑制剂治疗长期病毒学失败期间表型药物敏感性和病毒复制能力的演变
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