Markowitz Steven B, Levin Kate
Center for the Biology of Natural Systems, Queens College, City University of New York, NY, USA.
J Occup Environ Med. 2004 Feb;46(2):154-60. doi: 10.1097/01.jom.0000111602.76443.15.
Ortho-toluidine (o-toluidine), an aromatic amine, is classified by the International Agency for Research on Cancer as a probable human carcinogen. A cohort study published in 1991 reported a 6.5-fold excess incidence of bladder cancer in a chemical plant that used o-toluidine. We report 19 additional cases of bladder cancer among workers in this cohort, yielding a total of 34 cases of bladder cancer in the cohort to date. The number of bladder cancers diagnosed in the recent period has increased. The timing of onset of exposure to o-toluidine of numerous cases of bladder cancer after 1968, and especially 1975, suggests that potentially confounding occupational exposures other than o-toluidine were not responsible for the observed excess bladder cancer. A formal cohort update is strongly indicated. This study further supports the human bladder carcinogenicity of o-toluidine.
邻甲苯胺是一种芳香胺，被国际癌症研究机构列为可能的人类致癌物。1991年发表的一项队列研究报告称，在一家使用邻甲苯胺的化工厂中，膀胱癌发病率高出6.5倍。我们报告了该队列中另外19例膀胱癌病例，使该队列迄今的膀胱癌病例总数达到34例。近期诊断出的膀胱癌病例有所增加。1968年之后，尤其是1975年之后，众多膀胱癌病例接触邻甲苯胺的起始时间表明，除邻甲苯胺之外，其他潜在的混杂职业暴露并非观察到的膀胱癌超额发病的原因。强烈建议进行正式的队列更新。本研究进一步支持邻甲苯胺对人类膀胱具有致癌性。
