Kodama Tatsuo, Tane Nobuhiro, Ohira Akihiro, Maruyama Riruke, Fukuyama Junichiro
Department of Ophthalmology, Shimane Medical University, Izumo, Japan.
Jpn J Ophthalmol. 2004 Jan-Feb;48(1):7-11. doi: 10.1007/s10384-003-0006-2.
Sclerosing sweat duct carcinoma (SSDC) is a rare variant of sweat gland carcinomas. We report a case of SSDC of the eyelid.
A 33-year-old woman presented with a painless, slowly enlarging nodule in her left lower eyelid. Incisional biopsy revealed proliferated ducts lined by two layers of epithelium embedded in a dense fibrous stroma. Cytologic atypia was not evident. Initial histopathological diagnosis was a syringoma or an inflammatory reaction.
Four years after initial biopsy, the mass had enlarged slightly. Madarosis was observed thereafter. The lesion was excised completely with frozen section evaluation of the margins and repaired by a semicircular rotation flap. Microscopically, variable sized tubular structures could be seen invading the deep dermis and muscle. The final diagnosis was SSDC.
This tumor is seldom recognized and is frequently confused with benign syringoma or inflammation. Wide and deep excisional biopsy is necessary for correct diagnosis and successful treatment.
硬化性汗腺导管癌（SSDC）是汗腺癌的一种罕见变体。我们报告一例眼睑SSDC病例。
一名33岁女性，左眼下睑出现一个无痛、缓慢增大的结节。切开活检显示，导管增生，由两层上皮细胞衬里，嵌入致密的纤维基质中。细胞学异型性不明显。最初的组织病理学诊断为汗管瘤或炎症反应。
初次活检四年后，肿块略有增大。此后观察到睫毛脱落。病变通过边缘冷冻切片评估完全切除，并用半圆形旋转皮瓣修复。显微镜下可见大小不一的管状结构侵入深层真皮和肌肉。最终诊断为SSDC。
这种肿瘤很少被识别，常与良性汗管瘤或炎症混淆。为了正确诊断和成功治疗，进行广泛而深入的切除活检是必要的。
