日本精神分裂症患者肿瘤坏死因子α（TNF-α）基因-308G>A启动子多态性的关联分析。
Association analysis of the -308G>A promoter polymorphism of the tumor necrosis factor alpha (TNF-alpha) gene in Japanese patients with schizophrenia.
作者信息
Hashimoto R, Yoshida M, Ozaki N, Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Tatsumi M, Kamijima K, Kunugi H
机构信息
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
出版信息
J Neural Transm (Vienna). 2004 Feb;111(2):217-21. doi: 10.1007/s00702-003-0101-z.
Two research groups have thus far reported a significant association between schizophrenia and a promoter polymorphism (-308G > A) of the gene encoding tumor necrosis factor alpha (TNF-alpha), while contradictive negative results have also been reported. We examined the possible association in a Japanese sample of 297 schizophrenia cases and 458 controls. Allele frequencies of both the patients and controls were very low (1.5% and 0.8%, respectively), and the difference was not statistically significant. We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-alpha gene.
迄今为止，两个研究小组报告了精神分裂症与编码肿瘤坏死因子α（TNF-α）的基因启动子多态性（-308G>A）之间存在显著关联，不过也有相互矛盾的阴性结果报道。我们在一个由297例精神分裂症患者和458名对照组成的日本样本中检验了这种可能的关联。患者和对照的等位基因频率都非常低（分别为1.5%和0.8%），且差异无统计学意义。我们得出结论，-308G>A多态性对精神分裂症发病的影响即便存在也是微弱的，大多数日本精神分裂症患者与TNF-α基因的-308G>A多态性无关。
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