Kreimer Aimee R, Alberg Anthony J, Daniel Richard, Gravitt Patti E, Viscidi Rapheal, Garrett Elizabeth S, Shah Keerti V, Gillison Maura L
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21231, USA.
J Infect Dis. 2004 Feb 15;189(4):686-98. doi: 10.1086/381504. Epub 2004 Feb 2.
The prevalence and risk factors for oral human papillomavirus (HPV) infection are unknown, despite evidence for an etiological role for HPV in oral cancers. Oral samples from human immunodeficiency virus (HIV)-seronegative (n=396) and HIV-seropositive (n=190) adults were tested for HPV DNA. High-risk HPV infections were present in 2.1% of tonsil and 6.3% of oral-rinse specimens. The prevalence of oral high-risk HPV infection was greater in HIV-seropositive individuals (13.7% vs. 4.5%; P<.001). In multiple logistic regression, odds of oral HPV infection increased with age, male sex, and herpes simplex virus (HSV)-2 seropositivity in HIV-seronegative individuals and with CD4 cell count <200 cells/mL, HSV-2 seropositivity, oral mucosal abnormalities, and >1 oral sex partner during the previous year (odds ratio, 12.8; 95% confidence interval, 3.1-52.7) among HIV-seropositive individuals. HPV type 16, which is present in most HPV-associated tonsillar cancers, was the most prevalent high-risk oral HPV infection.
尽管有证据表明人乳头瘤病毒（HPV）在口腔癌中具有病因学作用，但口腔HPV感染的患病率及风险因素仍不清楚。对人类免疫缺陷病毒（HIV）血清阴性（n = 396）和HIV血清阳性（n = 190）成年人的口腔样本进行了HPV DNA检测。在2.1%的扁桃体样本和6.3%的口腔冲洗样本中发现了高危HPV感染。HIV血清阳性个体的口腔高危HPV感染患病率更高（13.7%对4.5%；P<0.001）。在多因素logistic回归分析中，HIV血清阴性个体中，口腔HPV感染几率随年龄、男性性别和单纯疱疹病毒2型（HSV-2）血清阳性而增加；在HIV血清阳性个体中，口腔HPV感染几率随CD4细胞计数<200个/毫升、HSV-2血清阳性、口腔黏膜异常以及前一年有超过1个口交性伴侣而增加（比值比为12.8；95%置信区间为3.1 - 52.7）。在大多数与HPV相关的扁桃体癌中出现的HPV 16型是最常见的高危口腔HPV感染类型。
