Boda M, Németh I
Department of Pediatrics, Albert Szent-Györgyi University of Medical School, Szeged, Hungary.
Acta Paediatr Hung. 1992;32(3):241-55.
The erythrocyte glutathione metabolism of 11 children with acute celiac disease (CD), 11 children under gluten free diet with CD and 5 children with cow's milk allergy was compared to that of 11 children with nutritive iron deficiency and to 22 healthy children as controls. Erythrocyte glutathione (GSH) content of celiac children was elevated and the glutathione disulfide (GSSG) level was significantly decreased as compared to normal controls. Erythrocyte GSSG/GSH ratio in acute CD differed also from the one in iron deficiency. In vitro oxidative load of acetylphenylhydrazine proved the impaired glutathione stability of the erythrocytes in acute CD and cow's milk allergy. A parallel rise of methemoglobin and hemichrome level of blood cells was seen. Further on, the selenium content of the red blood cells of CD patients decreased. All alterations of the erythrocyte tended to normalize during the dietetic period. These data suggest a reduced protective capacity of erythrocytes in CD and in cow's milk allergy in childhood against oxidizing stresses.
将11名患有急性乳糜泻（CD）的儿童、11名接受无麸质饮食的CD儿童和5名牛奶过敏儿童的红细胞谷胱甘肽代谢与11名营养性缺铁儿童以及22名健康儿童作为对照进行了比较。与正常对照组相比，乳糜泻儿童的红细胞谷胱甘肽（GSH）含量升高，而谷胱甘肽二硫化物（GSSG）水平显著降低。急性CD患者的红细胞GSSG/GSH比值也与缺铁患者不同。乙酰苯肼的体外氧化负荷证明急性CD和牛奶过敏患者红细胞的谷胱甘肽稳定性受损。血细胞的高铁血红蛋白和半色素水平同时升高。此外，CD患者红细胞中的硒含量降低。在饮食期间，红细胞的所有变化都趋于正常化。这些数据表明，儿童期CD和牛奶过敏患者的红细胞对氧化应激的保护能力降低。
