Martelossi S, Ventura A, Perticarari S, Not T, Anibal J
Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italia.
Pediatr Med Chir. 1993 Jan-Feb;15(1):45-51.
It has been suggested that high serum level of food proteins antibodies (especially cow's milk protein antibodies) may have a specific meaning in the diagnosis of food allergy, especially presenting with gastrointestinal complaints. In our study we tested with enzyme-linked immunoabsorbent assay test (ELISA) the antibody serum level to cow's milk and soy proteins in 123 children. The following patients were included in the study: 30 children with cow's milk enteropathy (CME), 27 children with soy proteins intolerance (SI), 19 coeliac children on gluten containing diet (CD), 9 coeliac children on gluten free diet (GFD) and 50 healthy sex and age matched control children. All coeliac patients had assumed cow's milk and soy proteins at the moment of the test or a few days before. Higher antibody serum level was found in coeliac disease to both cow's milk and soy proteins and in cases with cow's and soy allergy, than in control cases. The highest mean value of cow's milk and soy proteins antibodies have been found in the untreated coeliac children (CD), also higher than in the two groups of specific allergy. In treated coeliac children (GFD) with normalized jejunal mucosa cow's milk and soy proteins antibodies was normal. None of the 19 CD with high cow's milk and soy proteins antibodies level showed clinical intolerance to cow's milk and soy proteins.(ABSTRACT TRUNCATED AT 250 WORDS)
有人提出，高血清水平的食物蛋白抗体（尤其是牛奶蛋白抗体）在食物过敏的诊断中可能具有特定意义，特别是在出现胃肠道不适症状时。在我们的研究中，我们采用酶联免疫吸附测定试验（ELISA）检测了123名儿童血清中针对牛奶和大豆蛋白的抗体水平。研究纳入了以下患者：30名患有牛奶肠病（CME）的儿童、27名对大豆蛋白不耐受（SI）的儿童、19名食用含麸质饮食的乳糜泻儿童（CD）、9名食用无麸质饮食的乳糜泻儿童（GFD）以及50名年龄和性别匹配的健康对照儿童。所有乳糜泻患者在检测时或检测前几天都摄入了牛奶和大豆蛋白。与对照病例相比，乳糜泻患者以及牛奶和大豆过敏患者的血清抗体水平更高。在未经治疗的乳糜泻儿童（CD）中，牛奶和大豆蛋白抗体的平均水平最高，也高于两组特异性过敏患者。在空肠黏膜恢复正常的接受治疗的乳糜泻儿童（GFD）中，牛奶和大豆蛋白抗体水平正常。19名牛奶和大豆蛋白抗体水平高的CD患者中，没有一人表现出对牛奶和大豆蛋白的临床不耐受。（摘要截选至250字）
