Breuer Michael, Ditrich Klaus, Habicher Tilo, Hauer Bernhard, Kesseler Maria, Stürmer Rainer, Zelinski Thomas
BASF Aktiengesellschaft, Forschung Feinchemikalien & Biokatalyse, 67056 Ludwigshafen, Germany.
Angew Chem Int Ed Engl. 2004 Feb 6;43(7):788-824. doi: 10.1002/anie.200300599.
Enantiomerically pure amino acids, amino alcohols, amines, alcohols, and epoxides play an increasingly important role as intermediates in the pharmaceutical industry and agrochemistry, where both a high degree of purity and large quantities of the compounds are required. The chemical industry has primarily relied upon established chemical methods for the synthesis of these intermediates, but is now turning more and more to enzymatic and biotechnological fermentation processes. For the industrial implementation of many transformations alternative methods are available. The advantages of the individual methods will be discussed herein and exemplified by syntheses of relevant compounds.
对映体纯的氨基酸、氨基醇、胺、醇和环氧化物作为中间体在制药工业和农业化学中发挥着越来越重要的作用，在这些领域中，既需要高纯度，又需要大量的化合物。化学工业主要依靠成熟的化学方法来合成这些中间体，但现在越来越多地转向酶促和生物技术发酵工艺。对于许多转化反应的工业实施，有多种替代方法可供选择。本文将讨论各种方法的优点，并通过相关化合物的合成举例说明。
