Baeza Isabel, Leyva Emma, Campos Begoña, Lara Mónica, Ibáñez Miguel, Farfán Norberto, Orozco Héctor, Flores-Romo Leopoldo, Hernández-Pando Rogelio, Wong Carlos
Department of Biochemistry, National School of Biological Sciences, National Polytechnic Institute, México City, México.
Eur J Immunol. 2004 Feb;34(2):576-86. doi: 10.1002/eji.200324177.
Antibodies recognizing non-bilayer phospholipid arrangements (NPA) in membrane models and in cell membranes in vivo, triggered an autoimmune-like disease in mice. This exhibited features similar to human lupus and was induced by injecting mice either with the H308 monoclonal antibody specific to NPA, with sera from mice which already had developed the autoimmune disease, or with liposomes treated with the NPA inductors chlorpromazine or procainamide; or with these NPA inductors alone. All these procedures revealed the involvement of antibodies to non-bilayer phospholipids in inducing this autoimmune-like disease. Unraveling the mechanisms of these antibodies might contribute to a better understanding of the molecular and immunological basis of autoimmune diseases like lupus and, hopefully, towards the development of better therapeutic strategies.
识别膜模型和体内细胞膜中非双层磷脂排列（NPA）的抗体，在小鼠中引发了一种类似自身免疫性的疾病。这种疾病表现出与人类狼疮相似的特征，通过向小鼠注射对NPA特异的H308单克隆抗体、来自已经患上自身免疫性疾病的小鼠的血清、用NPA诱导剂氯丙嗪或普鲁卡因胺处理过的脂质体，或者单独使用这些NPA诱导剂均可诱发。所有这些操作都揭示了针对非双层磷脂的抗体在诱发这种类似自身免疫性疾病中的作用。阐明这些抗体的作用机制可能有助于更好地理解狼疮等自身免疫性疾病的分子和免疫基础，并有望推动更好的治疗策略的开发。
