Taylor-Robinson D, Gilroy C B, Thomas B J, Hay P E
Division of Medicine, Imperial College London, St Mary's Hospital, London W2 1NY, UK.
Int J STD AIDS. 2004 Jan;15(1):21-5. doi: 10.1258/095646204322637209.
Seventy-eight men with a history of chronic urethritis were referred for investigation. Of 52 men diagnosed as having persistent or recurrent non-gonococcal urethritis (NGU) at the time of referral, 11 (21%) were infected with Mycoplasma genitalium and three with Chlamydia trachomatis. Men who were M. genitalium-positive had not previously received less antibiotic, in terms of treatment duration, than those who were M. genitalium-negative, suggesting a possible resistance to the antibiotics given. In the current investigation, of 11 M. genitalium-positive men with persistent or recurrent NGU who were treated for four to six weeks with erythromycin, 500 mg four times daily, nine (82%) responded clinically and microbiologically, but later six relapsed without M. genitalium being detected. The results of observing and investigating a patient for about one year, the only one to have concurrent chlamydial and mycoplasmal infections, is presented, a feature being the intermittent persistence of the mycoplasma.
78名有慢性尿道炎病史的男性被转诊进行调查。在转诊时被诊断为患有持续性或复发性非淋菌性尿道炎（NGU）的52名男性中，11名（21%）感染了生殖支原体，3名感染了沙眼衣原体。就治疗持续时间而言，生殖支原体阳性的男性之前接受的抗生素治疗并不比生殖支原体阴性的男性少，这表明可能对所用抗生素产生了耐药性。在本次调查中，11名患有持续性或复发性NGU且生殖支原体阳性的男性，每天4次、每次500毫克服用红霉素治疗4至6周，9名（82%）在临床和微生物学方面有反应，但后来6名复发，未检测到生殖支原体。本文呈现了对一名同时感染衣原体和支原体的患者进行约一年观察和调查的结果，其一个特点是支原体间歇性持续存在。
