通过对喹哪啶进行维尔斯迈尔-哈克反应分离4-氯-3-甲酰基-2-(2-羟基乙烯-1-基)喹啉：二氮杂环庚三烯并喹啉杂环的构建及其抗菌和细胞遗传学研究
Isolation of 4-chloro-3-formyl-2-(2-hydroxyethene-1-yl) quinolines by Vilsmeier Haack reaction on quinaldines: Construction of diazepino quinoline heterocycles and their antimicrobial and cytogenetic studies.
作者信息
Kumar Raju Nandha, Suresh Thangaraj, Mohan Palathurai Subraminiam
机构信息
Department of Chemistry, Bharathiar University, Coimbatore--641 046, India.
出版信息
Acta Pharm. 2003 Mar;53(1):1-13.
PMID:14769247
Abstract
Application of Vilsmeier conditions to 4-hydroxyquinaldines gives 4-chloro-3-formyl-2-(2-hydroxyethene-1-yl)-quinolines as an intermediate. The latter is utilized to prepare diazepino quinolines on treatment with phenylhydrazine hydrochloride. All the synthesized compounds have been screened for their antibacterial and antifungal as well as cytogenetic activities.
摘要
将维尔斯迈尔条件应用于4-羟基喹哪啶可得到4-氯-3-甲酰基-2-(2-羟基乙烯-1-基)喹啉作为中间体。后者在用盐酸苯肼处理时用于制备二氮杂环庚三烯并喹啉。所有合成的化合物都已针对其抗菌、抗真菌以及细胞遗传学活性进行了筛选。
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