Signorini Liana, Barbi Maria, Matteelli Alberto, Binda Sandro, Didò Patrizia, Caroppo Simona, Primache Valeria, Pisani Salvatore, Messino Crescenzo, Brunelli Maria, Costa Paolo, Ronca Enrico, Fausti Caterina, Castelli Francesco
Institute of Infectious and Tropical Diseases, University of Brescia, Italy.
J Travel Med. 2004 Jan-Feb;11(1):34-6. doi: 10.2310/7060.2004.13651.
Immunization against poliomyelitis is recommended for international travelers to developing countries. However, the level of antibodies varies even in previously unvaccinated persons, due to wild-type or vaccine-type infections in the eldest travelers.
In 1999, we conducted a seroprevalence study in the Lombardy region (northern Italy), using sera collected in 1994 from a population aged 50 to 59 years. The study subjects were consecutive, randomly selected travelers enrolled in an anti-hepatitis A virus antibody study. Neutralizing antibodies were titrated on Vero cells in microtiter plates. Each serum dilution (1:8 to 1:256) was challenged against 100 tissue culture infective doses of the three Sabin strains. Titers> 1:8 were considered to be protective.
We studied 98 travelers, 59 male and 39 female, of mean age 54 years. Seventy-three (74.4%) reported previous travel abroad, but none had been vaccinated against polio. Dietary habits included consumption of seafood in 74.4% and raw vegetables from their own garden in 52.1%. The seroprevalences for neutralizing antibodies against poliovirus type 1, type 2 and type 3 were 86.7%, 89.9%, and 86.7%, respectively. All travelers presented protective antibody titers against at least one of the three viral types. Protective antibody titers were unrelated to travel history or dietary habit.
A high proportion of the previously unvaccinated adults in our sample presented protective immunity to polioviruses. This observation may have implications for cost-effectiveness analysis of generalized polio vaccination in adult Italian travelers.
建议前往发展中国家的国际旅行者接种脊髓灰质炎疫苗。然而，由于年长旅行者中存在野生型或疫苗型感染，即使是以前未接种过疫苗的人，其抗体水平也存在差异。
1999年，我们在伦巴第地区（意大利北部）进行了一项血清流行率研究，使用的血清是1994年从50至59岁的人群中收集的。研究对象是参加甲型肝炎病毒抗体研究的连续随机选择的旅行者。在微量滴定板中，在Vero细胞上滴定中和抗体。将每种血清稀释液（1:8至1:256）用三种萨宾株的100个组织培养感染剂量进行攻击。滴度>1:8被认为具有保护性。
我们研究了98名旅行者，其中59名男性和39名女性，平均年龄54岁。73人（74.4%）报告以前出过国，但没有人接种过脊髓灰质炎疫苗。饮食习惯包括74.4%的人食用海鲜，52.1%的人食用自家花园种植的生蔬菜。针对脊髓灰质炎病毒1型、2型和3型的中和抗体血清流行率分别为86.7%、89.9%和86.7%。所有旅行者对三种病毒类型中的至少一种呈现出保护性抗体滴度。保护性抗体滴度与旅行史或饮食习惯无关。
我们样本中以前未接种过疫苗的成年人中有很大比例对脊髓灰质炎病毒具有保护性免疫力。这一观察结果可能对意大利成年旅行者普遍接种脊髓灰质炎疫苗的成本效益分析有影响。
