Veronesi L, Affanni P, Verrotti di Pianella C, Colucci M E, Tanzi M L
Department of Biomedical Biotechnological and Translational Science, Unit of Public Health, University of Parma,Italy.
Ann Ig. 2013 Sep-Oct;25(5):427-33. doi: 10.7416/ai.2013.1944.
This cross-sectional seroprevalence study was carried out in 2007 to estimate the immunological status associated with poliomyelitis among fertile women , according to demographic changes. We consecutively enrolled 493 healthy mothers at the time of delivery in order to assess immunity against poliomyelitis by a neutralisation inhibition test. Despite the lack of seronegative subjects, our investigation showed low GMTs, which confirmed a reduction in the "booster effect". The GMTs against poliovirus 1, poliovirus 2 and poliovirus 3 were 25.20, 14.79 and 8.80, respectively. The data that emerged from our survey showed that GMTs have decreased significantly since 1983 and reached low-to-medium values over the past 25 years. The serum prevalence studies, together with the vaccination coverage estimates, are useful and are strongly recommended in order to highlight and identify the possible scenarios in which susceptible subject groups may be present simultaneously as well the possibility of the reintroduction of wild virus in an area that was previously free of polio.
这项横断面血清流行率研究于2007年开展，旨在根据人口结构变化评估育龄妇女中与脊髓灰质炎相关的免疫状况。我们在分娩时连续招募了493名健康母亲，以便通过中和抑制试验评估其对脊髓灰质炎的免疫力。尽管缺乏血清阴性受试者，但我们的调查显示中和抗体滴度较低，这证实了“加强效应”的降低。针对脊髓灰质炎病毒1型、脊髓灰质炎病毒2型和脊髓灰质炎病毒3型的中和抗体滴度分别为25.20、14.79和8.80。我们调查得出的数据显示，自1983年以来中和抗体滴度显著下降，并在过去25年达到中低水平。血清流行率研究以及疫苗接种覆盖率估计是有用的，强烈建议开展这些研究，以突出和确定可能同时存在易感人群的情况，以及先前无脊髓灰质炎地区重新引入野生病毒的可能性。
