Singer Adam J, Thode Henry C
Department of Emergency Medicine, Stony Brook Health Sciences Center, L3-058, Stony Brook University, Stony Brook, NY 11794-8350, USA.
Am J Surg. 2004 Feb;187(2):238-48. doi: 10.1016/j.amjsurg.2003.11.017.
Octylcyanoacrylate is a medical grade topical tissue adhesive that has been approved for closing surgical incisions and traumatic lacerations. We reviewed animal and human studies that evaluated its use for a variety of surgical indications and specialties. We also performed a meta-analysis of all clinical trials using octylcyanoacrylate.
Animal and human studies published in peer-reviewed articles as well as published abstracts. A search of Medline was performed using the MESH terms: tissue adhesives, cyanoacrylates, and octylcyanoacrylate.
The current review and metanalysis demonstrate that octylcyanoacrylate can be used successfully in a wide variety of clinical and surgical settings for multiple types of wounds covering most of the surface of the human body. Prior knowledge of the limitations and technical aspects specific to wound closure with octylcyanoacrylate as well as appropriate wound selection and preparation will help ensure optimal results.
氰基丙烯酸辛酯是一种医用级局部组织粘合剂，已被批准用于闭合手术切口和外伤性撕裂伤。我们回顾了评估其在各种手术适应症和专科中使用情况的动物和人体研究。我们还对所有使用氰基丙烯酸辛酯的临床试验进行了荟萃分析。
发表在同行评审文章以及已发表摘要中的动物和人体研究。使用医学主题词（MESH）：组织粘合剂、氰基丙烯酸酯和氰基丙烯酸辛酯对医学文献数据库（Medline）进行了检索。
当前的综述和荟萃分析表明，氰基丙烯酸辛酯可成功用于多种临床和手术环境，用于覆盖人体大部分表面的多种类型伤口。事先了解氰基丙烯酸辛酯伤口闭合的局限性和技术方面以及适当的伤口选择和准备工作将有助于确保获得最佳效果。
