Barzon Luisa, Boscaro Marco, Palù Giorgio
Department of Histology, Microbiology, and Medical Biotechnologies, University of Padova, I-35121 Padua, Italy.
Endocr Rev. 2004 Feb;25(1):1-44. doi: 10.1210/er.2002-0035.
The field of cancer gene therapy is in continuous expansion, and technology is quickly moving ahead as far as gene targeting and regulation of gene expression are concerned. This review focuses on the endocrine aspects of gene therapy, including the possibility to exploit hormone and hormone receptor functions for regulating therapeutic gene expression, the use of endocrine-specific genes as new therapeutic tools, the effects of viral vector delivery and transgene expression on the endocrine system, and the endocrine response to viral vector delivery. Present ethical concerns of gene therapy and the risk of germ cell transduction are also discussed, along with potential lines of innovation to improve cell and gene targeting.
癌症基因治疗领域正在不断扩展，就基因靶向和基因表达调控而言，技术正在迅速发展。本综述聚焦于基因治疗的内分泌方面，包括利用激素和激素受体功能来调节治疗性基因表达的可能性、使用内分泌特异性基因作为新的治疗工具、病毒载体递送和转基因表达对内分泌系统的影响，以及对病毒载体递送的内分泌反应。还讨论了当前基因治疗的伦理问题和生殖细胞转导的风险，以及改善细胞和基因靶向的潜在创新方向。
