碳酸氢盐反应性“可溶性”腺苷酸环化酶定义了一个核环磷酸腺苷微区。
Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain.
作者信息
Zippin Jonathan H, Farrell Jeanne, Huron David, Kamenetsky Margarita, Hess Kenneth C, Fischman Donald A, Levin Lonny R, Buck Jochen
机构信息
Department of Pharmacology, Joan and Sanford I. Weill Medical College and Graduate School of Medical Sciences of Cornell University, 1300 York Ave., New York, NY 10021, USA.
出版信息
J Cell Biol. 2004 Feb 16;164(4):527-34. doi: 10.1083/jcb.200311119. Epub 2004 Feb 9.
Bicarbonate-responsive "soluble" adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of this complete and functional, nuclear-localized cAMP pathway establishes that cAMP signals in intracellular microdomains and identifies an alternate pathway leading to CREB activation.
对碳酸氢盐有反应的“可溶性”腺苷酸环化酶部分存在于哺乳动物细胞核内，在那里它刺激核蛋白激酶A的活性，使环磷酸腺苷反应元件结合蛋白（CREB）磷酸化。这种完整且有功能的核定位环磷酸腺苷途径的存在表明环磷酸腺苷在细胞内微区发出信号，并确定了一条导致CREB激活的替代途径。
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