Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8, Tampa, FL, 33612, USA.
Fluids Barriers CNS. 2022 Mar 20;19(1):23. doi: 10.1186/s12987-022-00322-2.
Adenylyl cyclases (ADCYs), by generating second messenger cAMP, play important roles in various cellular processes. Their expression, regulation and functions in the CNS, however, remain largely unknown. In this review, we first introduce the classification and structure of ADCYs, followed by a discussion of the regulation of mammalian ADCYs (ADCY1-10). Next, the expression and function of each mammalian ADCY isoform are summarized in a region/cell-specific manner. Furthermore, the effects of GPCR-ADCY signaling on blood-brain barrier (BBB) integrity are reviewed. Last, current challenges and future directions are discussed. We aim to provide a succinct review on ADCYs to foster new research in the future.
腺苷酸环化酶（ADCYs）通过生成第二信使 cAMP，在各种细胞过程中发挥重要作用。然而，它们在中枢神经系统中的表达、调节和功能仍知之甚少。在这篇综述中，我们首先介绍了 ADCYs 的分类和结构，然后讨论了哺乳动物 ADCYs（ADCY1-10）的调节。接下来，我们以区域/细胞特异性的方式总结了每种哺乳动物 ADCY 同工型的表达和功能。此外，还综述了 GPCR-ADCY 信号对血脑屏障（BBB）完整性的影响。最后，讨论了当前的挑战和未来的方向。我们旨在提供一个简洁的 ADCYs 综述，以促进未来的新研究。
