Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Org Biomol Chem. 2004 Feb 21;2(4):446-8. doi: 10.1039/b315037b. Epub 2004 Jan 16.
Phosphine oxides were found to be efficient neutral coordinate-organocatalysts (NCOs) for the allylation of N-acylhydrazones. Among the phosphine oxides tested, a three carbon-tethered bisphosphine oxide (dppp dioxide) was found to be the most effective, and in the presence of dppp dioxide, less reactive aromatic and [small alpha],[small beta]-unsaturated N-acylhydrazones underwent allylation as well as diastereoselective crotylation. Furthermore, a polymer-supported phosphine oxide was also developed as an effective immobilized NCO.
氧化膦被发现是有效的中性配位有机催化剂（NCO），可用于 N-酰基腙的烯丙基化反应。在所测试的氧化膦中，三碳键合双氧化膦（dppp 二氧化物）被发现是最有效的，并且在 dppp 二氧化物的存在下，反应性较低的芳香族和[小 alpha]，[小 beta]-不饱和 N-酰基腙也能进行烯丙基化以及立体选择性的巴豆基化反应。此外，还开发了一种聚合物负载的氧化膦作为有效的固定化 NCO。
