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[首发精神分裂症且未治疗病程较长的早期疾病进程——一项对照研究]

[Early course of illness in first episode schizophrenia with long duration of untreated illness - a comparative study].

作者信息

Köhn D, Niedersteberg Antje, Wieneke Anke, Bechdolf A, Pukrop R, Ruhrmann S, Schultze-Lutter Frauke, Maier W, Klosterkötter J

机构信息

Klinik für Psychiatrie und Psychotherapie der Universität zu Köln.

出版信息

Fortschr Neurol Psychiatr. 2004 Feb;72(2):88-92. doi: 10.1055/s-2003-812509.

Abstract

When a long duration of untreated illness (DUI) is correlated with an unfavourable progression of schizophrenia in the same way as that of a long duration of untreated psychosis (DUP), the characteristics of patients with a long DUI are of particular interest for early recognition and early intervention programmes. With this background, demographic data and early symptoms were collected from 82 first time in-patients with schizophrenia using the IRAOS (Interview for the Retrospective Assessment of the Onset of Schizophrenia). In the total sample, the average DUI was almost 5.9 years. On the basis of the DUI median (5.2 yrs), the random sample was divided into two groups: one with long (n = 41) and one with short (n = 41) DUI. When comparing both groups in terms of socio-demographic data, no significant differences could be found (with the exception of age at first admission: 28 - 32 yrs). On a psychopathological level, patients with long DUI were prone to depressive moods, anxiety, compulsive symptoms and showed early signs of disturbances in bodily perception. An educational campaign should sensitize both employees working in primary care and experts who diagnose and treat psychological illnesses, to the fact that these symptoms could point to a prodrome even when the patient has passed the typical age of being at risk from schizophrenia.

摘要

当未治疗疾病持续时间(DUI)与精神分裂症的不良进展之间的关联方式与未治疗精神病持续时间(DUP)相同时,长期DUI患者的特征对于早期识别和早期干预计划尤为重要。在此背景下,使用IRAOS(精神分裂症发病回顾性评估访谈)从82名首次住院的精神分裂症患者中收集了人口统计学数据和早期症状。在整个样本中,平均DUI几乎为5.9年。根据DUI中位数(5.2年),将随机样本分为两组:一组为长期DUI(n = 41),另一组为短期DUI(n = 41)。在比较两组的社会人口统计学数据时,未发现显著差异(首次入院年龄除外:28 - 32岁)。在精神病理学层面,长期DUI患者容易出现抑郁情绪、焦虑、强迫症状,并表现出身体感知障碍的早期迹象。一项教育活动应使基层医疗工作人员以及诊断和治疗心理疾病的专家都认识到,即使患者已超过精神分裂症的典型高危年龄,这些症状也可能指向前驱期。

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