Galińska Beata, Szulc Agata, Czernikiewicz Andrzej
Klinika Psychiatrii AM w Białymstoku.
Psychiatr Pol. 2005 Sep-Oct;39(5):859-68.
Duration of untreated psychosis (DUP) is associated with poor premorbid functioning and poor outcome in patients with schizophrenia. The authors determined whether the duration of untreated psychosis was associated with severity of clinical symptoms and neurocognitive functioning in patients with first-episode schizophrenia.
A total of 30 first-episode patients were evaluated by means of WCST, Vocabulary, Arithmetic, Block Design, attention and verbal fluency tests.
The mean duration of untreated psychosis was 31.3 weeks. The group was divided on the basis of median duration of untreated psychosis (10 weeks) to short and long DUP group. There were no significant differences between the groups in results of clinical symptoms and neurocognitive functioning. There were no correlations between severity of clinical symptoms and neurocognitive functioning with duration of untreated psychosis.
In the group of patients with first-episode schizophrenia, the duration of untreated psychosis is not associated with severity of clinical symptoms and neurocognitive functioning.
未治疗精神病持续时间（DUP）与精神分裂症患者病前功能不良及预后较差相关。作者确定了未治疗精神病持续时间是否与首发精神分裂症患者的临床症状严重程度和神经认知功能相关。
通过威斯康星卡片分类测验（WCST）、词汇、算术、积木设计、注意力和言语流畅性测试对30例首发患者进行评估。
未治疗精神病的平均持续时间为31.3周。根据未治疗精神病的中位持续时间（10周）将该组分为DUP短组和DUP长组。两组在临床症状结果和神经认知功能方面无显著差异。临床症状严重程度和神经认知功能与未治疗精神病持续时间之间无相关性。
在首发精神分裂症患者组中，未治疗精神病持续时间与临床症状严重程度和神经认知功能无关。
