Cohen H A, Ashkenazi A, Nussinovitch M, Gross S, Frydman M
Department of Pediatrics, Hasharon Hospital, Sackler School of Medicine, Tel Aviv University, Petach Tikvah, Israel.
Ann Pharmacother. 1992 Nov;26(11):1378-9. doi: 10.1177/106002809202601107.
To report two cases of fixed drug eruption induced by methylphenidate.
Two children with attention deficit disorder treated with methylphenidate as a simple drug developed fixed drug eruption of the scrotum. Drug discontinuation was followed by a complete resolution of the skin eruption. Rechallenge resulted in the same drug rash. Macrophage migration-inhibiting factor (MIF) assay with methylphenidate was positive.
The pathogenesis of fixed drug eruption and the role of MIF assay in the diagnosis of adverse drug reaction is discussed.
Fixed drug rash induced by methylphenidate is a possible but rare phenomenon.
报告两例由哌甲酯引起的固定型药疹病例。
两名患有注意力缺陷障碍的儿童单纯使用哌甲酯进行治疗，出现了阴囊固定型药疹。停药后皮疹完全消退。再次用药引发了相同的药疹。对哌甲酯进行的巨噬细胞移动抑制因子（MIF）检测呈阳性。
探讨了固定型药疹的发病机制以及MIF检测在药物不良反应诊断中的作用。
哌甲酯引起的固定型药疹是一种可能但罕见的现象。
