盐酸羟嗪所致阴茎固定性药疹。
Fixed drug eruption of the penis due to hydroxyzine hydrochloride.
作者信息
Cohen H A, Barzilai A, Matalon A, Harel L, Gross S
机构信息
Department of Family Medicine, Sackler School of Medicine, Tel Aviv University, Petach Tikvah, Israel.
出版信息
Ann Pharmacother. 1997 Mar;31(3):327-9. doi: 10.1177/106002809703100311.
OBJECTIVE
To report four cases of fixed drug eruption induced by hydroxyzine hydrochloride (Otarex, Teva, Israel).
CASE SUMMARY
Four children with restlessness who were treated with hydroxyzine hydrochloride developed fixed drug eruption of the penis. Drug discontinuation was followed by complete resolution of the skin eruption. Rechallenge resulted in the same drug rash. Macrophage migration inhibiting factor (MIF) assay with hydroxyzine hydrochloride was positive.
DISCUSSION
The pathogenesis of fixed drug eruption and the role of macrophage MIF assay in diagnosis is discussed.
CONCLUSIONS
A fixed drug eruption induced by hydroxyzine hydrochloride is possible, but is a rare phenomenon.
目的
报告4例由盐酸羟嗪（以色列梯瓦制药公司生产的奥塔雷克）引起的固定性药疹病例。
病例摘要
4例接受盐酸羟嗪治疗的烦躁不安儿童出现阴茎固定性药疹。停药后皮疹完全消退。再次用药引发了相同的药疹。盐酸羟嗪巨噬细胞移动抑制因子（MIF）检测呈阳性。
讨论
讨论了固定性药疹的发病机制以及巨噬细胞MIF检测在诊断中的作用。
结论
盐酸羟嗪可引起固定性药疹，但这是一种罕见现象。
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