Holowiecki J, Koehler M, Zintl Z, Kardos G, Lutz D, Krzemien S, Rewesz T, Brugiatelli M, Callea V, Kachel L
Clinic of Haematology, Silesian Medical Academy, Katowice, Poland.
Leuk Lymphoma. 1992 Jun;7(3):225-34. doi: 10.3109/10428199209053627.
The prognostic significance of immunophenotype and other features including sex, age, anaemia, WBC, FAB type, and PAS staining were analysed in a group of 389 children newly diagnosed as acute lymphoblastic leukemia (ALL) and treated according to the BFM 1981/1983 protocol. The CR rate was higher (82-94%) in immunophenotypic subgroups defined as 'non-B' compared with B-ALL (54%). The probability of being in CCR at the end of follow up was 0.68 (median. observation, 3 years). Using the stepwise Cox regression analysis the following independent factors predictive of duration of CCR were selected (relative risk in brackets): 1. WBC (> 25G/1:< 25G/1 = 2.0, P = 0.0008), 2. age (> 10y:2-10y = 1.3, P = 0.04), 3. CALLA positivity (neg.:posit. = 2.4, P = 0.04), 4. CALLA within B-cell progenitor ALL (pre;preB,Calla-:Calla+ = 1.7, P = 0.007). T-ALL appeared to have a worse prognosis than U-ALL and B-progenitor derived ALL but it did not retain independent prognostic significance in multivariate analysis.
对一组389例新诊断为急性淋巴细胞白血病（ALL）并按照BFM 1981/1983方案进行治疗的儿童，分析了免疫表型及其他特征（包括性别、年龄、贫血、白细胞、FAB分型和PAS染色）的预后意义。定义为“非B”的免疫表型亚组的完全缓解（CR）率（82 - 94%）高于B系ALL（54%）。随访结束时持续完全缓解（CCR）的概率为0.68（中位观察时间3年）。采用逐步Cox回归分析，选择了以下预测CCR持续时间的独立因素（括号内为相对风险）：1. 白细胞（> 25G/1：< 25G/1 = 2.0，P = 0.0008），2. 年龄（> 10岁：2 - 10岁 = 1.3，P = 0.04），3. 普通急性淋巴细胞白血病抗原（CALLA）阳性（阴性：阳性 = 2.4，P = 0.04），4. B细胞祖细胞ALL中的CALLA（前体；前B，CALLA阴性：CALLA阳性 = 1.7，P = 0.007）。T系ALL的预后似乎比未分化型ALL和B祖细胞来源的ALL更差，但在多变量分析中它不具有独立的预后意义。
