血清素依赖性大脑激活：甲硫噻吨及其他血清素能拮抗剂的作用。

Serotonin-dependent cerebral activation: effects of methiothepin and other serotonergic antagonists.

作者信息

Watson N V, Hargreaves E L, Penava D, Eckel L A, Vanderwolf C H

机构信息

Psychology Department, University of British Columbia, Vancouver, Canada.

出版信息

Brain Res. 1992 Nov 27;597(1):16-23. doi: 10.1016/0006-8993(92)91500-e.

DOI:10.1016/0006-8993(92)91500-e

PMID:1477730

Abstract

In scopolamine-treated (5.0 mg/kg, s.c.) rats hippocampal rhythmical slow activity (RSA) and neocortical low voltage fast activity (LVFA) occur only in close correlation with head movements, spontaneous changes in posture, or locomotion (Type I behavior). Previous work indicates that such scopolamine-resistant RSA and LVFA are dependent on ascending serotonergic projections. A test of 9 serotonergic antagonists (methiothepin; ritanserin; ketanserin; pizotifen; mianserin; pirenperone; ICS-205-930; metoclopramide; methysergide) showed that methiothepin produces a partial reduction in RSA and LVFA in scopolamine-treated rats, while the other antagonists are completely inactive over a wide range of doses. It may be that serotonergic cerebral activation depends on both 5-HT1 and 5-HT2 receptors.

摘要

在经东莨菪碱处理（5.0毫克/千克，皮下注射）的大鼠中，海马节律性慢活动（RSA）和新皮质低电压快活动（LVFA）仅与头部运动、姿势的自发变化或运动（I型行为）密切相关。先前的研究表明，这种对东莨菪碱有抗性的RSA和LVFA依赖于上行5-羟色胺能投射。对9种5-羟色胺能拮抗剂（甲硫噻嗪；利坦色林；酮色林；匹莫齐特；米安色林；哌仑西平；ICS-205-930；甲氧氯普胺；麦角新碱）的测试表明，甲硫噻嗪可使经东莨菪碱处理的大鼠的RSA和LVFA部分降低，而其他拮抗剂在广泛的剂量范围内完全无活性。5-羟色胺能脑激活可能同时依赖于5-HT1和5-HT2受体。