Vanderwolf C H, Stewart D J
Physiol Behav. 1986;38(1):57-65. doi: 10.1016/0031-9384(86)90132-0.
Previous research has indicated that low voltage fast activity (LVFA) in the neocortex and rhythmical slow activity (RSA) in the hippocampus can result from activity in either (or both) the cholinergic corticipetal projections from the basal forebrain and the serotonergic corticipetal projections from the brainstem raphe. These inputs appear to give rise, respectively, to atropine-sensitive LVFA and RSA and atropine-resistant LVFA and RSA. The atropine-sensitive and atropine-resistant waveforms have been shown to have distinctive behavioral correlates. The present experiments extend these findings by providing dose-response data on the effects of scopolamine and Ditran on neocortical activity in relation to behavior in the rat. In addition, new evidence is presented which indicates that neuroleptic drugs reduce activity in the atropine-resistant (presumably serotonergic) inputs to the hippocampus and neocortex by an indirect action involving dopamine receptors. A single dose of d-amphetamine or apomorphine appears to increase activity in the same pathway by a similar indirect action. These findings may be relevant to the psychiatric effects of neuroleptic drugs.
先前的研究表明，新皮层中的低电压快速活动（LVFA）和海马体中的节律性慢活动（RSA）可能源于基底前脑的胆碱能向皮质投射和脑干中缝核的5-羟色胺能向皮质投射中的任一者（或两者）的活动。这些输入似乎分别产生对阿托品敏感的LVFA和RSA以及对阿托品耐受的LVFA和RSA。已证明对阿托品敏感和耐受的波形具有独特的行为相关性。本实验通过提供东莨菪碱和地卓西平对大鼠新皮层活动与行为关系的剂量反应数据，扩展了这些发现。此外，还提供了新的证据，表明抗精神病药物通过涉及多巴胺受体的间接作用，降低了海马体和新皮层中对阿托品耐受（可能是5-羟色胺能）输入的活动。单剂量的右旋苯丙胺或阿扑吗啡似乎通过类似的间接作用增加了同一通路的活动。这些发现可能与抗精神病药物的精神效应有关。
