Kapitola J, Andrle J, Kubícková J
Laborator pro endokrinologii a metabolismus a III. interní klinika, 1. lékarská fakulta Univerzity Karlovy, Praha.
Cas Lek Cesk. 1992 Nov 20;131(23):705-6.
In an experiment on 38 75-day-old female rats--sham-operated or oophorectomized (OOX)--the authors assessed the effect of hydrocortisone administration (0.01% in the diet for four weeks) on the blood flow in the tibia and distal end of the femur (uptake of 85Sr microparticles). In the tibia they assessed also the density (according to the Archimed principle) and the weight of ashes per volume unit of bone. OOX increases significantly local circulation in both bones. After hydrocortisone these values are significantly lower in sham-operated and OOX rats as compared with controls and also significantly lower in the group OOX+hydrocortisone, as compared with group OOX. The density and weight of ashes from the tibia are not affected by hydrocortisone; the minute volume of the heart per 100 g body weight of rats is not altered in any group. The mechanism of the described hydrocortisone effects on circulation is not known. In the discussion the authors indicate possible associations of blood flow and the osteoblast and prostaglandin function in bony tissue.
在一项针对38只75日龄雌性大鼠（假手术组或卵巢切除组）的实验中，作者评估了给予氢化可的松（在饮食中添加0.01%，持续四周）对胫骨和股骨远端血流（85Sr微粒摄取量）的影响。在胫骨方面，他们还根据阿基米德原理评估了骨密度以及每单位体积骨的灰分重量。卵巢切除显著增加了两根骨头的局部血液循环。给予氢化可的松后，假手术组和卵巢切除组大鼠的这些值与对照组相比显著降低，并且与卵巢切除组相比，卵巢切除+氢化可的松组的值也显著降低。胫骨的灰分密度和重量不受氢化可的松影响；每100克大鼠体重的心脏每分钟输出量在任何组中均未改变。氢化可的松对循环系统产生上述影响的机制尚不清楚。在讨论中，作者指出了血流与骨组织中成骨细胞和前列腺素功能之间可能存在的关联。
