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南非南部加兰夸瓦地区轮状病毒感染的分子流行病学

The molecular epidemiology of rotavirus infection in Ga-Rankuwa, southern Africa.

作者信息

Bos P, Mnisi Y N, Steele A D

机构信息

Department of Virology, Medical University of Southern Africa Ga-Rankuwa.

出版信息

Cent Afr J Med. 1992 Jul;38(7):286-90.

PMID:1477877
Abstract

Rotaviruses were detected in 32.8 pc (96/292) of stool specimens collected from infants and young children with gastroenteritis attending the rehydration unit at Ga-Rankuwa Hospital between January and December 1989. A seasonal distribution was observed with an increase in numbers shedding the virus during the colder months of the year. Based on variations in the migration pattern of the RNA genome segments when passed through polyacrylamide gels, seven different RNA electrophoretypes were identified; 82 pc of the patients had virus with long patterns and 17 pc with short patterns. A mixed infection was observed in one case with both a long and a short virus. A single dominant long electrophoretype persisted throughout the 12 month study period, whereas the other minor types co-circulated at varying intervals.

摘要

1989年1月至12月期间,从加兰夸医院补液科收治的患有肠胃炎的婴幼儿粪便标本中,检出轮状病毒的比例为32.8%(96/292)。观察到病毒存在季节性分布,在一年中较寒冷的月份里排毒的人数增加。根据RNA基因组片段在聚丙烯酰胺凝胶中迁移模式的差异,鉴定出七种不同的RNA电泳型;82%的患者感染的病毒呈现长模式,17%呈现短模式。有一例观察到同时感染了长模式和短模式病毒的混合感染情况。在为期12个月的研究期间,单一优势长电泳型持续存在,而其他次要类型则以不同间隔共同流行。

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引用本文的文献

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Prevalence, Pattern and Genetic Diversity of Rotaviruses among Children under 5 Years of Age with Acute Gastroenteritis in South Africa: A Systematic Review and Meta-Analysis.南非 5 岁以下急性胃肠炎患儿轮状病毒的流行率、模式和遗传多样性:系统评价和荟萃分析。
Viruses. 2021 Sep 23;13(10):1905. doi: 10.3390/v13101905.
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Epidemiology of rotavirus diarrhoea in Africa: a review to assess the need for rotavirus immunization.非洲轮状病毒腹泻的流行病学:一项评估轮状病毒免疫需求的综述
Bull World Health Organ. 1998;76(5):525-37.