Li C
Institute of Preclinical Sciences, Norman Bethune University of Medical Sciences, Changchun.
Zhonghua Bing Li Xue Za Zhi. 1992 Jun;21(3):183-5.
The alteration of myocardial capillary permeability (MCP) in experimental diabetic rat was investigated by using cationic ferritin as a tracer. Diabetes was induced by injection of streptozocin (70mg/kg b.w.ip.). Vehicle injected, age and body weight-matched rats were served as the controls. The myocardial tissue was examined by the end of 2,7, and 9 months or even longer after diabetes induction. Results showed that (1) MCP was significantly increased in diabetic rats in comparing with that of the controls; (2) The increase of permeability became more pronounced with prolongation of the course of diabetes; and (3) the increase of MCP preceded the capillary basal laminar thickening demonstrated by electron microscopy. These findings suggest that increased MCP may play a role in the pathogenesis of basal laminar thickening and myocardial complications in diabetic state.
以阳离子铁蛋白为示踪剂，研究实验性糖尿病大鼠心肌毛细血管通透性（MCP）的变化。通过腹腔注射链脲佐菌素（70mg/kg体重）诱导糖尿病。注射溶媒、年龄和体重匹配的大鼠作为对照。在糖尿病诱导后2、7、9个月甚至更长时间结束时检查心肌组织。结果显示：（1）与对照组相比，糖尿病大鼠的MCP显著增加；（2）随着糖尿病病程的延长，通透性增加更为明显；（3）MCP的增加先于电子显微镜显示的毛细血管基底膜增厚。这些发现表明，MCP增加可能在糖尿病状态下基底膜增厚和心肌并发症的发病机制中起作用。
