急性淋巴细胞白血病患儿身高增长速度对性早熟的预测

Prediction of advanced puberty by height velocity in children with acute lymphoblastic leukemia.

作者信息

Kawasaki H, Azuma E, Washio S, Taneda H, Kubo M, Ido M, Sakurai M

机构信息

Department of Pediatrics, Mie University School of Medicine, Japan.

出版信息

Horm Res. 1992;37(3):81-5. doi: 10.1159/000182287.

DOI:10.1159/000182287

PMID:1478627

Abstract

Pubertal development was retrospectively evaluated in 58 children with cancer, mostly acute lymphoblastic leukemia (ALL), who are in complete remission and off chemotherapy. Six girls [5 patients with ALL, and 1 with malignant lymphoma (NHL)] showed advanced puberty (25.0%, 6 of 24 female patients with ALL and NHL) through the evaluation of their growth velocity. No evidence for advanced puberty was seen in the males. All 6 girls had received cranial irradiation for central nervous system prophylaxis and systemic chemotherapy including glucocorticoid. The mean age at onset of the pubertal growth spurt in these 6 girls was significantly lower than for girls with a solid tumor [6.90 +/- 0.10 and 9.00 +/- 0.77 (mean +/- SD) years, respectively (p < 0.01)]. By simply evaluating the height velocity, we could predict advanced puberty which was ultimately associated with short stature.

摘要

对58名癌症患儿（大多为急性淋巴细胞白血病，ALL）进行了青春期发育的回顾性评估，这些患儿处于完全缓解期且已停止化疗。通过生长速度评估，6名女孩（5例ALL患者和1例恶性淋巴瘤，NHL）出现青春期提前（25.0%，24例ALL和NHL女性患者中的6例）。男性未发现青春期提前的证据。所有6名女孩均接受过中枢神经系统预防性颅脑照射和包括糖皮质激素在内的全身化疗。这6名女孩青春期生长突增开始的平均年龄显著低于实体瘤女孩[分别为6.90±0.10岁和9.00±0.77岁（均值±标准差），p<0.01]。通过简单评估身高速度，我们可以预测最终与身材矮小相关的青春期提前。