Vandenbergh D J, Persico A M, Hawkins A L, Griffin C A, Li X, Jabs E W, Uhl G R
Laboratory of Molecular Neurobiology, National Institute on Drug Abuse, Baltimore, MD 21224.
Genomics. 1992 Dec;14(4):1104-6. doi: 10.1016/s0888-7543(05)80138-7.
The human dopamine transporter (DAT1) gene is localized to chromosome 5p15.3 by in situ hybridization and PCR amplification of rodent somatic cell hybrid DNA. Analysis of a 40-bp repeat in the 3' untranslated region of the message revealed variable numbers of the repeat ranging from 3 to 11 copies. These results will aid in the investigation of a role for this gene in genetic disorders of the dopaminergic system in humans.
通过原位杂交以及对啮齿动物体细胞杂交DNA的PCR扩增，人类多巴胺转运体（DAT1）基因定位于5号染色体短臂15.3区。对该信使RNA 3'非翻译区一个40碱基对重复序列的分析显示，该重复序列的拷贝数在3至11个之间变化。这些结果将有助于研究该基因在人类多巴胺能系统遗传疾病中的作用。
