Slierendregt B L, van Noort J T, Bakas R M, Otting N, Jonker M, Bontrop R E
Institute of Applied Radiobiology and Immunology, TNO, Department of Chronic and Infectious Diseases, Rijswijk, The Netherlands.
Hum Immunol. 1992 Sep;35(1):29-39. doi: 10.1016/0198-8859(92)90092-2.
Sequence analysis of rhesus monkey (Macaca mulatta) polymorphic second exon of major histocompatibility complex class II DRB subregion genes demonstrates the existence of at least 34 alleles. Some of these rhesus monkey alleles are very similar (or nearly identical) to HLA-DRB alleles. These data demonstrate that members of the lineages for Mhc-DRB103, -DRB104, -DRB1*10, and the loci of Mhc-DRB3, -DRB4, -DRB5, and -DRB6 predate speciation of man and rhesus monkey and were already present 25 million years ago. Calculation of evolutionary rates suggests that the various allele lineages have differential stabilities. Furthermore, the data indicate that distinct species may not have inherited or lost transspecies Mhc-DRB lineages in evolution, because several allele lineages in rhesus monkeys appear to be absent in humans and vice versa.
恒河猴（猕猴）主要组织相容性复合体II类DRB亚区基因多态性第二外显子的序列分析表明至少存在34个等位基因。这些恒河猴等位基因中的一些与HLA - DRB等位基因非常相似（或几乎相同）。这些数据表明，Mhc - DRB103、- DRB104、- DRB1*10谱系成员以及Mhc - DRB3、- DRB4、- DRB5和- DRB6基因座早于人类和恒河猴的物种形成，在2500万年前就已存在。进化速率的计算表明，各种等位基因谱系具有不同的稳定性。此外，数据表明不同物种在进化过程中可能没有继承或丢失跨物种的Mhc - DRB谱系，因为恒河猴中的几个等位基因谱系在人类中似乎不存在，反之亦然。
