Milutinović B, Gudović R, Malesević J
Dept. Physiology, Medical Faculty, Hajduk Veljkova, Yugoslavia.
J Hirnforsch. 1992;33(4-5):357-60.
In the development of nervous system, two processes are of a particular interest. It is well known that after a primary migration of cells, there appears a consecutive regression in cellular number, closely connected with the maturation of the nervous system. The dynamics of this reduction was investigated following the changes in number of cells in nucleus hypoglossus as well as that of Purkinje cells in two structures of cerebellar cortex--in vermis and in hemispheres. Cell nuclei were counted using the stereological technique, after a usual preparation. Data were collected from 20 human brains of different gestation age, i.e. at 12.5, 14, 17.5, 19.5, 24, 31, weeks of gestation and 6 day old newborn. After the graphical and numerical analysis of the data obtained, an adequate mathematical model was proposed. It is confirmed that a close agreement between biological data and decreasing two-exponential equation can be demonstrated, pointing out that the cellular reduction shows a proportional relation. The possible explanation could be that only the cells forming proper and useful connections and entering the informational system have a privilege to survive, and that all improper contacts lead to the rejection of cells or even of groups of cells.
在神经系统的发育过程中，有两个过程特别引人关注。众所周知，在细胞进行初次迁移后，细胞数量会出现连续减少，这与神经系统的成熟密切相关。通过观察舌下神经核以及小脑皮质两个结构（蚓部和半球）中浦肯野细胞数量的变化，对这种减少的动态过程进行了研究。在常规制片后，使用体视学技术对细胞核进行计数。数据取自20个不同妊娠年龄的人类大脑，即妊娠12.5周、14周、17.5周、19.5周、24周、31周以及出生6天的新生儿。在对所获数据进行图形和数值分析后，提出了一个合适的数学模型。证实了生物学数据与递减双指数方程之间存在密切的一致性，表明细胞减少呈现出比例关系。可能的解释是，只有形成适当且有用连接并进入信息系统的细胞才有存活的特权，而所有不适当的接触都会导致细胞甚至细胞群被淘汰。
