Gudović R, Milutinović B
Dept. of Anatomy, Faculty of Medicine, Novi Sad, Yugoslavia.
J Hirnforsch. 1996;37(1):67-72.
Human fetal brains were investigated in order to establish the regressional process in two directly dependent structures: in the inferior olivary nucleus and in cerebellar Purkinje cells. Inferior olivary nucleus is the main origin of the climbing fibres, that form one of two direct input systems into the cerebellum. For the purpose 25 fetal human brains at various stages of development (12.5, 15, 16.5 19.5 24, and 31 postovulatory week), together with one brain of newborn (in further text: 41. postovulatory week) were used. Numerical density of nuclei in both regions was determined by stereological technique. In both structures appeared a reduction in the number of nuclei, showing specific dynamics during the intrauterine maturation. The data obtained were analyzed by graphical and numerical method, that allowed the formation of the adequate mathematical models for both structures, that precisely described their regression changes. The data presented indicate that the reduction is very pronounced until the 18-19 postovulatory week, and after that time it is remarkable slowed down. That period is therefore the probable breakpoint of the appearance of synaptic contacts between climbing fibres and Purkinje cell dendrites.
为了确定两个直接相关结构（下橄榄核和小脑浦肯野细胞）中的退化过程，对人类胎儿大脑进行了研究。下橄榄核是攀缘纤维的主要起源，而攀缘纤维构成了进入小脑的两个直接输入系统之一。为此，使用了25个处于不同发育阶段（排卵后12.5、15、16.5、19.5、24和31周）的人类胎儿大脑，以及一个新生儿大脑（在下文：排卵后41周）。通过体视学技术确定了这两个区域中细胞核的数值密度。在这两个结构中，细胞核数量均出现减少，在子宫内成熟过程中呈现出特定的动态变化。通过图形和数值方法对获得的数据进行了分析，从而为这两个结构建立了合适的数学模型，精确描述了它们的退化变化。所呈现的数据表明，在排卵后18 - 19周之前，减少非常明显，之后则显著减缓。因此，这个时期可能是攀缘纤维与浦肯野细胞树突之间突触接触出现的断点。
