Marino C, Cividalli A
Department of Biological and Health Effects, ENEA CRE Casaccia, Roma, Italy.
Int J Hyperthermia. 1992 Nov-Dec;8(6):771-81. doi: 10.3109/02656739209005025.
The effect of one or more heat treatments at 43 degrees C combined with conventional multifraction irradiation was studied in murine normal and tumoral tissues. The endpoint of this study was the TCD50 of the C3H mammary carcinoma, inoculated into the foot. For normal tissue the reaction of the skin of the foot was assessed according to a graded scoring system. Twenty X-ray fractions delivered in 20 or 26 days were combined with one, four or eight fractions of quasi-simultaneous or sequential hyperthermia (i.e. heat applied 4 h after irradiation). Tumour dose-response curves show a decrease in TCD50 and in increase in TER linked to the increasing number of heat sessions. A qualitatively similar effect of the number of sessions was observed for the different protocols (quasi-simultaneous and sequential) and for the two overall times. No significant difference was measured between one and four HT sessions plus 20 fx of RT in the normal tissue damage, while a slight difference was observed between one, four and eight HT sessions delivered with 20 fractions of RT in 26 days.
研究了43摄氏度下一次或多次热处理与传统多分割照射相结合对小鼠正常组织和肿瘤组织的影响。本研究的终点是接种于足部的C3H乳腺癌的50%肿瘤控制剂量（TCD50）。对于正常组织，根据分级评分系统评估足部皮肤的反应。在20天或26天内给予20次X射线分割，并与1次、4次或8次准同步或序贯热疗（即在照射后4小时施加热量）相结合。肿瘤剂量反应曲线显示，随着热疗次数的增加，TCD50降低，治疗增益比（TER）增加。对于不同方案（准同步和序贯）以及两种总治疗时间，观察到热疗次数具有定性相似的效果。在正常组织损伤方面，1次和4次热疗联合20次放疗之间未测得显著差异，而在26天内给予20次放疗的情况下，1次、4次和8次热疗之间观察到轻微差异。
