Overgaard J
Cancer. 1981 Sep 1;48(5):1116-23. doi: 10.1002/1097-0142(19810901)48:5<1116::aid-cncr2820480512>3.0.co;2-j.
The effect of fractionated radiation and hyperthermia was experimentally studied in a C3H mammary carcinoma and its surrounding skin. Simultaneous radiation and heat (42.5 C-60 minutes) with one or five fractions gave thermal enhancement ratios (TER) of approximately 2.5 in both tumor and surrounding skin, and no improved therapeutic effect was obtained. Five fractions of sequential treatment with heating four hours after radiation reduced the tumor TER to about 1.4, but when 72 hours were allowed between the fractions, no thermal enhancement of the skin was observed. Thus, an improved therapeutic ratio was observed. Clinically the combined treatment was studied in 12 patients with 49 metastases from malignant melanoma treated with different schedules of radiation and hyperthermia (approximately 43 C for 30 minutes). Simultaneous treatment with three fractions in eight days gave TER values in the skin between 1.2-1.4, but a similar effect was found in the tumor. Three fractions of sequential treatment in eight days did not produce any thermal enhancement of the skin response, but still presented an apparent gain of the tumor response, and so seemed to increase the therapeutic effect. Bases on these findings, the strategy for further clinical use of combined hyperthermia and radiation is discussed.
在C3H乳腺癌及其周围皮肤中对分次放疗和热疗的效果进行了实验研究。同时进行放疗和加热（42.5℃，60分钟），一次或五次分次治疗在肿瘤和周围皮肤中产生的热增强比（TER）约为2.5，未获得改善的治疗效果。放疗后4小时加热的五次序贯治疗使肿瘤TER降至约1.4，但当分次之间间隔72小时时，未观察到皮肤的热增强。因此，观察到了改善的治疗比。临床上，对12例有49处恶性黑色素瘤转移灶的患者采用不同的放疗和热疗方案（约43℃，30分钟）进行了联合治疗研究。在八天内分三次同时治疗，皮肤的TER值在1.2 - 1.4之间，但在肿瘤中也发现了类似效果。在八天内分三次序贯治疗未产生皮肤反应的任何热增强，但仍显示肿瘤反应有明显改善，因此似乎提高了治疗效果。基于这些发现，讨论了热疗与放疗联合进一步临床应用的策略。
