Boosalis M G, Gray D, Walker S, Sutliff S, Talwalker R, Mazumder A
Department of Clinical Sciences, University of Kentucky, Lexington 40536-0080.
J Med. 1992;23(3-4):175-93.
Due to the stress imposed by the process of bone marrow transplantation (BMT), we hypothesized that individuals receiving such a transplant underwent an acute phase response (APR). Circulating levels of C-reactive protein (CRP), haptoglobin (HAP), alpha-1 acid glycoprotein (AAG), ceruloplasmin (CER), zinc (Zn), copper (Cu), interleukin-6 (IL-6), albumin (ALB), and thyroxine-binding prealbumin (TBPA), were measured at baseline (Day -7), Day -4, Day 0 (Transplant Day), Day +2, +7, and weekly until day 28 in 14 adults receiving an autologous bone marrow transplant as Phase 1 treatment for various hematologic or solid tumor malignancies. Ten of 14 recipients survived, 9 of which had a significant increase in CRP (p = 0.012), HAP (p = 0.011), AAG (p = 0.002), and decrease in ALB (p = 0.002) and TBPA (p = 0.004) on Day +7, but not Day 0, after bone marrow reinfusion. These findings document the presence of an APR and suggest that the bone marrow transplant process (post reinfusion) initiates a stress response in the recipient.
由于骨髓移植（BMT）过程带来的压力，我们推测接受此类移植的个体经历了急性期反应（APR）。在14名接受自体骨髓移植作为各种血液系统或实体肿瘤恶性疾病一期治疗的成年人中，于基线期（第-7天）、第-4天、第0天（移植日）、第+2天、第+7天以及直至第28天每周测量循环中的C反应蛋白（CRP）、触珠蛋白（HAP）、α-1酸性糖蛋白（AAG）、铜蓝蛋白（CER）、锌（Zn）、铜（Cu）、白细胞介素-6（IL-6）、白蛋白（ALB）和甲状腺素结合前白蛋白（TBPA）水平。14名接受者中有10名存活，其中9名在骨髓回输后第+7天而非第0天，CRP（p = 0.012）、HAP（p = 0.011）、AAG（p = 0.002）显著升高，ALB（p = 0.002）和TBPA（p = 0.004）降低。这些发现证明了急性期反应的存在，并表明骨髓移植过程（回输后）在接受者中引发了应激反应。
