Gallicchio V S, Messino M J, Hulette B C, Hughes N K
Department of Medicine, Lucille P. Markey Cancer Center, University of Kentucky Medical Center, Lexington.
J Med. 1992;23(3-4):195-216.
Bone marrow transplantation (BMT) has become a widely used procedure in the treatment of numerous hematological and non-hematological clinical disorders. The preparative regimen used for marrow recipients is not without risk as the immunodeficient recipient is susceptible to life-threatening infections due to the inability of the marrow to engraft properly. The monovalent cation lithium has been demonstrated to influence regenerating hematopoiesis following the use of several agents known to suppress hematopoiesis. The following report summarizes our studies which have been designed to determine the rate of hematopoietic reconstitution in lethally irradiated mice that were transplanted with bone marrow cells, harvested from either syngeneic or allogeneic donor animals, treated with lithium or phosphate buffered saline (PBS). Transplanted recipients receiving marrow cells from lithium treated donors were evaluated for their survival, peripheral blood indices and several classes of hematopoietic progenitors (granulocyte, erythroid, and megakaryocyte). Transplanted animals that received marrow cells from either syngeneic or allogeneic donors treated with lithium demonstrated greater survival, increased recovery of peripheral indices and hematopoietic progenitors compared to PBS-treated controls. These results indicate that the use of lithium to treat the donor may be an effective procedure to enhance hematopoietic recovery and engraftment in the transplanted recipient. Because of its wide-ranging effects, the use of lithium as a single agent, may be more efficacious than administering several hematopoietic growth factors in order to achieve a similar response.
骨髓移植（BMT）已成为治疗多种血液系统和非血液系统临床疾病的广泛应用的方法。用于骨髓接受者的预处理方案并非没有风险，因为免疫缺陷的接受者由于骨髓无法正常植入而易受危及生命的感染。已证明单价阳离子锂在使用几种已知抑制造血的药物后会影响再生造血。以下报告总结了我们的研究，这些研究旨在确定接受来自同基因或异基因供体动物的骨髓细胞、并用锂或磷酸盐缓冲盐水（PBS）处理的经致死性照射的小鼠的造血重建率。对接受来自锂处理供体的骨髓细胞的移植接受者的存活情况、外周血指标和几类造血祖细胞（粒细胞、红细胞和巨核细胞）进行了评估。与PBS处理的对照组相比，接受来自用锂处理的同基因或异基因供体的骨髓细胞的移植动物表现出更高的存活率、外周指标和造血祖细胞的恢复增加。这些结果表明，使用锂处理供体可能是增强移植接受者造血恢复和植入的有效方法。由于其广泛的作用，使用锂作为单一药物可能比施用几种造血生长因子以获得类似反应更有效。
