Fang X P, Anderson J E, Smith D L, McLaughlin J L, Wood K V
Department of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, Indiana 47907.
J Nat Prod. 1992 Nov;55(11):1655-63. doi: 10.1021/np50089a015.
Gigantetronenin [1] and gigantrionenin [6], two new monotetrahydrofuran Annonaceous acetogenins each possessing a double bond along the hydrocarbon chain, have been isolated from the bark of Goniothalamus giganteus by the use of brine shrimp lethality for bioactivity-directed fractionation. The structures were elucidated based on spectroscopic and chemical methods. Compounds 1 and 6 both show selective and potent cytotoxicities to human tumor cells in culture as well as toxicity to brine shrimp. A known cytotoxic acetogenin, annomontacin [11], was also isolated from this plant. The biogenetic pathway of the acetogenins from G. giganteus is discussed.
利用卤虫致死法进行生物活性导向分离，从大花哥纳香的树皮中分离出了两种新的单四氢呋喃番荔枝内酯类化合物，即巨盘木宁[1]和巨盘木烯宁[6]，它们在碳氢链上均含有一个双键。通过光谱和化学方法阐明了其结构。化合物1和6对培养中的人肿瘤细胞均表现出选择性且强效的细胞毒性，同时对卤虫也有毒性。还从该植物中分离出了一种已知具有细胞毒性的番荔枝内酯类化合物，即番荔枝蒙他星[11]。本文讨论了大花哥纳香中番荔枝内酯类化合物的生物合成途径。
