来自三瓣木兰茎皮的具有生物活性的番荔枝内酯

Biologically active acetogenins from stem bark of Asimina triloba.

作者信息

Zhao G X, Rieser M J, Hui Y H, Miesbauer L R, Smith D L, McLaughlin J L

机构信息

Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Purdue University, West Lafayette, IN 47907.

出版信息

Phytochemistry. 1993 Jul;33(5):1065-73. doi: 10.1016/0031-9422(93)85024-l.

DOI:10.1016/0031-9422(93)85024-l

PMID:7764028

Abstract

In continuing our research with cytotoxic and pesticidal components from the stem bark of the North American paw paw, Asimina triloba, the novel cytotoxic monotetrahydrofuran Annonaceous acetogenins, cis- and trans-annonacin-A-one, cis- and trans-gigantetrocinone and cis-isoannonacin, in addition to the known compounds, trans-isoannonacin and squamolone, have been identified. Brine shrimp lethality testing was used to direct the fractionation. The structures were elucidated by spectral analysis and/or chemical synthesis. These acetogenins have potent cytotoxicities against the human tumour cell lines of A-549 (lung carcinoma), MCF-7 (breast carcinoma) and HT-29 (colon adenocarcinoma).

摘要

在继续对北美番荔枝（Asimina triloba）茎皮中的细胞毒性和杀虫成分进行研究时，除了已知化合物反式异番荔枝宁和鳞酮外，还鉴定出了新型细胞毒性单四氢呋喃番荔枝内酯、顺式和反式番荔枝acin - A - 酮、顺式和反式巨大菌素酮以及顺式异番荔枝acin。采用卤虫致死试验来指导分馏过程。通过光谱分析和/或化学合成确定了这些化合物的结构。这些番荔枝内酯对A - 549（肺癌）、MCF - 7（乳腺癌）和HT - 29（结肠腺癌）人肿瘤细胞系具有强大的细胞毒性。